Science & Partners
About HSP
The Hereditary Spastic Paraplegias (“the HSPs”) are a group of rare inherited diseases characterized by a progressing spastic gait impairment caused by neurodegeneration of fibers within the spinal cord. In complicated types of HSPs neurodegeneration may occur also in other neurons like in cortical or sub-cortical or peripheral structures. The video below shows some typical experience of affected individuals.
International Partners
Euro-HSP works in close cooperation with the Tom Wahlig Foundation (TWF) - a German charity providing world wide support for HSP research. The TWF is organizing the leading annual symposium for HSP research. The Tom Wahlig Symposium takes place in Spring of each year at different locations in Germany. Please check out the TWF website for actual info.
Euro-HSP also works in close cooperation with the Spastic Paraplegia Foundation (SPF) in the USA. The SPF is the largest patient community worldwide and a continuous driver of HSP research in North America and around the globe.
Some of the info below will get up-dated.
This video focuses on someone who has been diagnosed with SPG4 so it won't be applicable to everyone, considering that, so far, over 90 genes have been identified with HSP. He also mistakenly says that HSP is a rare disease that affects the lower motor neurons. However, it affects the upper motor neurons.
Here is a link to clinical trials that have been completed or are recruiting:
| Understanding HSP disease in brief | more info |
|---|---|
| Promising treatment found for SPG5 HSP | more info |
| SPG7 more common in Australia | more info |
| Next generation gene testing telling a story | more info |
| Hereditary spastic paraplegia from 1880 to 2017: an historical review | more info |
| Chronic Pain | more info |
| Final QA with Craig Blackstone NIH on drug trials | more info |
| Management of HSP | more info |
| Recherce HSP publications articles | more info |
| Clinical trials designs | more info |
| Next generation molekylar diagnoses Italy | more info |
| Perspective on geomics on HSP |